<?xml version="1.0" encoding="UTF-8"?>
<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="certainty-type"/>
  <meta>
    <profile value="http://hl7.org/fhir/StructureDefinition/shareablecodesystem"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div value="&lt;div xmlns=&quot;http://www.w3.org/1999/xhtml&quot; xml:lang=&quot;en&quot; lang=&quot;en&quot;&gt;&lt;p class=&quot;res-header-id&quot;&gt;&lt;b&gt;Generated Narrative: CodeSystem certainty-type&lt;/b&gt;&lt;/p&gt;&lt;a name=&quot;certainty-type&quot;&gt; &lt;/a&gt;&lt;a name=&quot;hccertainty-type&quot;&gt; &lt;/a&gt;&lt;div style=&quot;display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%&quot;&gt;&lt;p style=&quot;margin-bottom: 0px&quot;&gt;Language: en&lt;/p&gt;&lt;p style=&quot;margin-bottom: 0px&quot;&gt;Profile: &lt;a href=&quot;http://hl7.org/fhir/R5/shareablecodesystem.html&quot;&gt;Shareable CodeSystem&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;&lt;p&gt;This case-sensitive code system &lt;code&gt;http://terminology.hl7.org/CodeSystem/certainty-type&lt;/code&gt; defines the following codes:&lt;/p&gt;&lt;table class=&quot;codes&quot;&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;&lt;b&gt;Code&lt;/b&gt;&lt;/td&gt;&lt;td&gt;&lt;b&gt;Display&lt;/b&gt;&lt;/td&gt;&lt;td&gt;&lt;b&gt;Definition&lt;/b&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;Overall&lt;a name=&quot;certainty-type-Overall&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Overall certainty&lt;/td&gt;&lt;td&gt;Overall certainty of evidence (quality of evidence).&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;RiskOfBias&lt;a name=&quot;certainty-type-RiskOfBias&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Risk of bias&lt;/td&gt;&lt;td&gt;methodologic concerns reducing internal validity.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;Inconsistency&lt;a name=&quot;certainty-type-Inconsistency&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Inconsistency&lt;/td&gt;&lt;td&gt;concerns that findings are not similar enough to support certainty.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;Indirectness&lt;a name=&quot;certainty-type-Indirectness&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Indirectness&lt;/td&gt;&lt;td&gt;concerns reducing external validity.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;Imprecision&lt;a name=&quot;certainty-type-Imprecision&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Imprecision&lt;/td&gt;&lt;td&gt;fuzzy or wide variability.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;PublicationBias&lt;a name=&quot;certainty-type-PublicationBias&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Publication bias&lt;/td&gt;&lt;td&gt;likelihood that what is published misrepresents what is available to publish.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;DoseResponseGradient&lt;a name=&quot;certainty-type-DoseResponseGradient&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Dose response gradient&lt;/td&gt;&lt;td&gt;higher certainty due to dose response relationship.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;PlausibleConfounding&lt;a name=&quot;certainty-type-PlausibleConfounding&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Plausible confounding&lt;/td&gt;&lt;td&gt;higher certainty due to risk of bias in opposite direction.&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td style=&quot;white-space:nowrap&quot;&gt;LargeEffect&lt;a name=&quot;certainty-type-LargeEffect&quot;&gt; &lt;/a&gt;&lt;/td&gt;&lt;td&gt;Large effect&lt;/td&gt;&lt;td&gt;higher certainty due to large effect size.&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;"/>
  </text>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cds"/>
  </extension>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="trial-use"/>
  </extension>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="1"/>
  </extension>
  <url value="http://terminology.hl7.org/CodeSystem/certainty-type"/>
  <version value="1.0.0"/>
  <name value="EvidenceCertaintyType"/>
  <title value="Evidence Certainty Type"/>
  <status value="active"/>
  <experimental value="false"/>
  <date value="2025-01-20T16:55:11+11:00"/>
  <publisher value="HL7 (FHIR Project)"/>
  <contact>
    <telecom>
      <system value="url"/>
      <value value="http://hl7.org/fhir"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="fhir@lists.hl7.org"/>
    </telecom>
  </contact>
  <description value="The aspect of quality, confidence, or certainty."/>
  <caseSensitive value="true"/>
  <valueSet value="http://terminology.hl7.org/ValueSet/certainty-type"/>
  <content value="complete"/>
  <concept>
    <code value="Overall"/>
    <display value="Overall certainty"/>
    <definition value="Overall certainty of evidence (quality of evidence)."/>
  </concept>
  <concept>
    <code value="RiskOfBias"/>
    <display value="Risk of bias"/>
    <definition value="methodologic concerns reducing internal validity."/>
  </concept>
  <concept>
    <code value="Inconsistency"/>
    <display value="Inconsistency"/>
    <definition value="concerns that findings are not similar enough to support certainty."/>
  </concept>
  <concept>
    <code value="Indirectness"/>
    <display value="Indirectness"/>
    <definition value="concerns reducing external validity."/>
  </concept>
  <concept>
    <code value="Imprecision"/>
    <display value="Imprecision"/>
    <definition value="fuzzy or wide variability."/>
  </concept>
  <concept>
    <code value="PublicationBias"/>
    <display value="Publication bias"/>
    <definition value="likelihood that what is published misrepresents what is available to publish."/>
  </concept>
  <concept>
    <code value="DoseResponseGradient"/>
    <display value="Dose response gradient"/>
    <definition value="higher certainty due to dose response relationship."/>
  </concept>
  <concept>
    <code value="PlausibleConfounding"/>
    <display value="Plausible confounding"/>
    <definition value="higher certainty due to risk of bias in opposite direction."/>
  </concept>
  <concept>
    <code value="LargeEffect"/>
    <display value="Large effect"/>
    <definition value="higher certainty due to large effect size."/>
  </concept>
</CodeSystem>